Guo Si-Cen graduated from Sichuan Conservatory of Music in 2016. She studied Erhu (Chinese Violin) with Professor Xiao Qian Yong. Between 2014 and 2015, she was the top student in her undergraduate studies. In 2014, Si-Cen joined the Chinese Folk Music Chamber Orchestra of the Sichuan Conservatory of Music. In addition, she often performs with the Chengdu Chinese Folk Music Orchestra.
In 2013, Si Cen was awarded the Silver Prize in the Master Xu Cup Erhu (Chinese Violin) competition. In 2015, she was awarded the Bronze Prize in the nationwide Poetry Rhyme Cup competition for Erhu.
In 2016, Si Cen began work at the Sichuan Province Art Research Institute.